Figure 4. H19 promotes invasion in PDAC cells.

(A and B) Matrigel invasion assays were performed using mock and H19-overexpressing cells (A) or Sc and H19-knockdown cells (B). ^**P < 0.01. (C) 3D invasion assays were performed using Sc and H19-knockdown cells. Representative images from Days 1, 5, and 16 are shown. The high-magnification images show that typical invasive cells were more numerous among Sc cells than H19-knockdown cells.