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. Author manuscript; available in PMC: 2019 Sep 1.

Published in final edited form as: Cancer Discov. 2018 Jul 16;8(9):1156–1175. doi: 10.1158/2159-8290.CD-17-1033

Table 1.

Genetic manipulation CD38 on tumor cells dramatically changes the tumor immune microenvironment.

Immune profile	LLC-JSP tumors						531LN3 tumors
	CD38 knockdown			CD38 overexpression			CD38 knockdown			CD38 overexpression
	Scr	shCD38	p value	Vector	CD38	p value	Scr	shCD38	p value	Vector	CD38	p value
% of CD8⁺ T cells	9.23 ± 1.39	16.36 ± 0.71	(0.0018)	10.41 ± 0.95	5.90 ± 0.92	(0.0093)	12.02 ± 1.57	18.08 ± 0.89	(0.0100)	14.60 ± 1.31	7.91 ± 1.02	(0.0037)
% of PD-1⁺TIM3⁺CD8⁺ T cells	23.44 ± 1.19	15.00 ± 1.56	(0.0026)	20.90 ± 1.63	30.78 ± 2.77	(0.0153)	19.26 ± 1.59	11.87 ± 1.41	(0.0084)	9.88 ± 1.98	52.36 ± 2.18	(0.0001)
% of IFN-γ⁺CD8⁺ T cells	7.62 ± 0.76	18.55 ± 0.84	(< 0.0001)	9.55 ± 0.65	5.09 ± 0.13	(0.0005)	12.80 ± 0.44	21.55 ± 0.82	(< 0.0001)	13.58 ± 0.49	4.14 ± 0.28	(0.0001)