Table 1.
Activity (Ki in μM) against WT and mutant IDH1.
| Cpd | R132H | R132C | WT |
|---|---|---|---|
| 2 | 4.1 | >50 | >50 |
| 9 | 1.2 | >50 | >50 |
| 10 | 0.6 | 36 | >50 |
| 11 | 0.8 | >50 | >50 |
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