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. Author manuscript; available in PMC: 2019 Oct 23.
Published in final edited form as: ACS Nano. 2018 Aug 29;12(10):9785–9799. doi: 10.1021/acsnano.7b08976

Figure 5. Multi-functionalized PLLA NF-SMS rescued bone resorption in a mouse periodontal disease model.

Figure 5.

a) MicroCT results show bone loss between the first and second molars in the periodontitis model and the bone volume changes in various treatment groups; b) The gene expression of gingival tissues was quantified using real-time PCR, showing the effector T cell cytokines IL-1β, TNF, IL17, anti-inflammatory cytokine IL-10, and osteogenic markers ALP and RUNX2; c) The flow cytometry analysis of the isolated gingival tissues show the percentage of Foxp3+ cells (gated on CD4-expressing cells) in different treatment groups. d) The IL17+ cells (gated on CD4-expressing cells) and the ratios of Treg/Th17 cells of the isolated gingival tissues were shown.