Table 1.
Predicted drug-gene interactions by DGIdb, ATC codes and nominally significant loci in the same LD block of the SNP presented
| Reported SNP | Gene | Interacting drug | ATC code 1 | ATC code 2 | ATC code 3 | GWAS predicted concordant phenotypes | GWAS predicted discordant phenotypes |
|---|---|---|---|---|---|---|---|
| rs11206510 | PCSK9 | EVOLOCUMAB | C10AX13 | LDL cholesterol, Total cholesterol, Triglycerides, Obesity class 2 | - | ||
| rs11206510 | PCSK9 | ALIROCUMAB | C10AX14 | LDL cholesterol, Total cholesterol, Triglycerides, Obesity class 2 | - | ||
| rs6088638 | ACSS2 | ADENOSINE TRIPHOSPHATE | C01EB10 | Triglycerides, Obesity class 2, Obesity class 1, BMI | - | ||
| rs264 | LPL | ORLISTAT | A08AB01 | Triglycerides, Type II diabetes, Obesity class 2, BMI | - | ||
| rs264 | LPL | CLOFIBRATE | C10AB01 | Triglycerides, Type II diabetes, Obesity class 2, BMI | - | ||
| rs264 | LPL | GEMFIBROZIL | C10AB04 | Triglycerides, Type II diabetes, Obesity class 2, BMI | - | ||
| rs4845625 | IL6R | TOCILIZUMAB | L04AC07 | LDL | - | ||
| rs1034565 | ARVCF | RISPERIDONE | N05AX08 | Type II diabetes, BMI | - | ||
| rs1034565 | ARVCF | BUPROPION | N06AX12 | Type II diabetes, BMI | - | ||
| rs11072794 | CHRNB4 | VARENICLINE | N07BA03 | Type II diabetes | - | ||
| rs11072794 | CHRNB4 | PENTOLINIUM | C02xxxx | Type II diabetes | - | ||
| rs11072794 | CHRNB4 | DEXTROMETHORPHAN | N07XX59 | R05DA09 | Type II diabetes | - | |
| rs11072794 | CHRNB4 | ETHANOL | V03AB16 | V03AZ01 | D08AX08 | Type II diabetes | - |
| rs11072794 | CHRNB4 | NICOTINE | N07BA01 | Type II diabetes | - | ||
| rs8111989 | CKM | CREATINE | C01EB06 | BMI | - | ||
| rs2023938 | HDAC9 | VORINOSTAT | L01XX38 | - | - | ||
| rs2023938 | HDAC9 | BELINOSTAT | L01XX49 | - | - | ||
| rs2023938 | HDAC9 | VALPROIC ACID | N03AG01 | - | - | ||
| rs2023938 | HDAC9 | PANOBINOSTAT | L01XX42 | - | - | ||
| rs2023938 | HDAC9 | ROMIDEPSIN | L01XX39 | - | - | ||
| rs7692387 | GUCY1A3 | RIOCIGUAT | C02KX05 | - | - | ||
| rs7642590 | MAP4 | PACLITAXEL | L01CD01 | Triglycerides | BMI | ||
| rs7642590 | MAP4 | DOCETAXEL | L01CD02 | Triglycerides | BMI | ||
| rs273909 | SLC22A4 | L-CARNITINE | A16AA01 | LDL, Total cholesterol, Triglycerides |