Table 2.
Most suitable drug targets according to predicted pocket interactions and nominally significant loci in the same LD block of the SNP presented
| Reported SNP | Genes | DoGSiteScorer pocket score | PDB code | GWAS predicted concordant phenotypes | GWAS predicted discordant phenotypes |
|---|---|---|---|---|---|
| rs1393786 | PPP2R3A | 0.85 | 4i5j | LDL cholesterol, Total cholesterol, Triglycerides, Obesity class 2, Obesity class 1, Obesity class 3, BMI | |
| rs2820315 | LMOD1 | 0.73 | 4z79 | Obesity class 2, Obesity class 1, Obesity class 3, BMI | |
| rs1167800 | HIP1 | 0.79 | 3i00 | Triglycerides, Obesity class 1, BMI | |
| rs15563 | UBE2Z | 0.73 | 5a4p | LDL cholesterol, Total cholesterol, Type II diabetes | |
| rs6544713 | ABCG8 | 0.89 | 5d07 | LDL cholesterol, Total cholesterol, Triglycerides | BMI |
| rs9326246 | BUD13, ZNF259, APO5A, APOA1 | 0.62 | 4uqt | LDL cholesterol, Total cholesterol, Triglycerides | LDL cholesterol |
| rs972158 | SNX10 | 0.73 | 4pzg | Triglycerides, Type II diabetes | |
| rs10797416 | SKI | 0.73 | 1sbx | LDL cholesterol, Total cholesterol | |
| rs12205331 | ANKS1A | 0.81 | 2lmr | Triglycerides, BMI | |
| rs7139492 | COL4A1 | 0.85 | 1li1 | Total cholesterol | |
| rs816889 | RND3 | 0.83 | 1m7b | Type II diabetes | |
| rs7173743 | MORF4L1 | 0.79 | 2f5j | Obesity class 2 | |
| rs10495907 | 7SK | Error | 2kx8 | LDL, Total cholesterol, Triglycerides, Type II diabetes, Obesity class 2, Obesity class 1, Obesity class 3, BMI | |
| rs2281727 | SMG6 | 0.89 | 4um2 | BMI | Total cholesterol |
| rs2294461 | LY86 | 0.82 | 3b2d | Type II diabetes | LDL |
| rs6984210 | BMP1 | 0.69 | 3edg |