Table 1.
Yeast Kinetochore Components With Known Human Orthologs
| Subcomplex | Yeast protein | Human Name | Subcomplex | Yeast protein | Human Name | Subcomplex | Yeast protein | Human Name |
|---|---|---|---|---|---|---|---|---|
| Cbf1 | Cbf1 | RBPJ | CCAN | Ctf19 | CENP-P | Dam1 | Dam1 | |
| Cbf3 | Cbf2 | Okp1 | CENP-Q | Dad1 | ||||
| Cep3 | Mcm21 | CENP-0 | Dad3 | |||||
| Ctf13 | Ame1 | CENP-U | Ask1 | |||||
| Skp1 | Iml3 | CENP-L | Duo1 | |||||
| Nucleosome and associated | Cse4 | CENP-A | Chl4 | CENP-N | Hsk3 | |||
| Hta2 | Histone H2A | Nkp1 | Spc19 | |||||
| Htb2 | Histone H2B | Nkp2 | Spc34 | |||||
| Hht1 | Histone H3 | Mem 16 | CENP-H | Dad2 | ||||
| Hhf1 | Histone H4 | Ctf3 | CENP-I | Dad4 | ||||
| Psh1 | Mcm22 | CENP-K | Motors | Kip3 | Kinesin-8 | |||
| Scm3 | Cnn1 | CENP-T | Cikl | Kinesin-14 | ||||
| Mif2 | Mif2 | CENP-C | Wip1 | CENP-W | Kar3 | Kinesin-14 | ||
| CPC | Ipl1 | Aurora B | Mhf1 | CENP-S | Cin8 | Kinesin-5 | ||
| Sli15 | INCENP | Mhf2 | CENP-X | Kip1 | BimC | |||
| Nbl1 | Borealin | Mtw1 | Mtw1 | Mis12 | MAPs | Stu2 | ChTOG | |
| Birl | Survivin | Nnf1 | Nnf1 | Stu1 | CLASP | |||
| Ns11 | Nsl1 | Slk19 | ||||||
| Dsn1 | Dsn1 | Bik1 | CLIP-170 | |||||
| Ndc80 | Ndc80 | HEC1 | SAC | Mps1 | Mps1 | |||
| Nuf2 | Nuf2 | Bub1 | Bub1 | |||||
| Spc24 | Spc24 | Bub3 | Bub3 | |||||
| Spc25 | Spc25 | Mad1 | Mad1 | |||||
| Spc105 | Spc105 | KNL1 | Mad2 | Mad2 | ||||
| Kre28 | Zwint | Mad3 | BubR1 |
Listed are the yeast proteins known to localize to the kinetochore and their corresponding human homologs. Shaded in gray are “core” kinetochore components that are structural elements that are conserved across most eukaryotes (van Hooff et al., 2017).
Adapted from Biggins, S. (2013). The composition, functions, and regulation of the budding yeast kinetochore. Genetics, 194(4), 817–846. https://doi.org/10.1534/genetics.112.145276 with subcomplex designation adapted from Pekgoz Altunkaya, G., Malvezzi, F., Demianova, Z., Zimniak, T., Litos, G., Weissmann, F., et al. (2016). CCAN assembly configures composite binding interfaces to promote cross-linking of Ndc80 complexes at the kinetochore. Current Biology, 26(17), 2370–2378. https://doi.org/10.1016/j.cub.2016.07.005.