Table 3b.

Results from Linear Mixed Effects Models for Log-Transformed eGFR with Random Intercepts and Slopes among Children with a Non-Glomerular CKD diagnosis.

	Model
Parameter	Null	Proteinuria only	FGF23 only	Proteinuria and FGF23
Level
Constant (Proteinuria= 0.45, FGF23= 110)	3.892 ± 0.017	3.906 ± 0.014	3.920 ± 0.015	3.926 ± 0.013
log2(Proteinuria/0.45)	0	−0.113 ± 0.008	0	−0.093 ± 0.008
log2(FGF23 / 110)	0	0	−0.188 ± 0.015	−0.149 ± 0.013
Slope (years from baseline)
Constant (Proteinuria= 0.45, FGF23= 110)	−0.051 ± 0.003	−0.048 ± 0.003	−0.049 ± 0.003	−0.048 ± 0.003
log2(Proteinuria/0.45)	0	−0.016 ± 0.002	0	−0.015 ± 0.002
log2(FGF23 / 110)	0	0	−0.015 ± 0.004	−0.008 ± 0.003
Random effects
S.D. (level) [σ1]	0.368	0.310	0.317	0.274
S.D. (slope) [σ2]	0.061	0.054	0.060	0.054
Correlation [$\frac{{\sigma }_{12}}{{\sigma }_1{\sigma }_2}$]	0.477	0.310	0.427	0.283
S.D. residual [σ]	0.111	0.111	0.111	0.111
AIC	−1239.604	−1418.868	−1363.118	−1513.796

Bold indicates p<0.05 for fixed effects. Estimates ± Standard errors. Corresponding 95% confidence intervals may be calculated as ±1.96 × Standard errors.

Abbreviations: S.D., standard deviation; FGF23, fibroblast growth factor 23; AIC, Akaike’s information criterion.