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. Author manuscript; available in PMC: 2019 Apr 5.
Published in final edited form as: Mol Cell. 2018 Mar 29;70(1):60–71.e15. doi: 10.1016/j.molcel.2018.02.026

Figure 1. Structure of Mtb RNAP-Lpm.

Figure 1.

A, Density map for Mtb RNAP-Lpm (left) and Lpm (right), colored by local resolution. B, Density and atomic model for Mtb RNAP-Lpm. Gray, RNAP core other than β′MtbSI; green, β′MtbSI; yellow, σ; green mesh, density map for Lpm; cyan, Lpm; violet sphere, RNAP active-center Mg2+. C, Atomic model for Mtb RNAP-Lpm. Colors as in B. D, RNAP-Lpm interactions (residues numbered as in Mtb RNAP and, in parentheses, as in Escherichia coli RNAP). Gray ribbons, RNAP backbone; gray sticks, RNAP carbon atoms; cyan sticks, Lpm carbon atoms; red, blue, and green sticks, oxygen, nitrogen, and chlorine atoms; dashed lines, H-bonds. E, Summary of RNAP-Lpm interactions. Blue arcs, van der Waals interactions; red dashed lines, H-bonds. See also Figs. S1-S4.