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. Author manuscript; available in PMC: 2019 Jul 3.
Published in final edited form as: Biochemistry. 2018 May 25;57(26):3590–3598. doi: 10.1021/acs.biochem.8b00218

Figure 5. Model for the stimulation of translation initiation by NS1.

Figure 5.

NS1 (yellow) bound to dsRNA (red) cannot bind to PABP1 (pink). NS1 that is not bound to dsRNA synergistically stimulates mRNA translation by binding to eIF4G (orange) and PABP1 to promote mRNA circularization. Also indicated are the m7G cap at the 5’-end of the mRNA (black circle), eIF4E (blue), and 80S ribosomes (green).