Table 3.
Coronary Heart Disease Factors by Thymic Irradiation Group
| Variable | % Irradiated (n) |
% Non-Irradiated | P-value (Ir vs. Non-ir) |
Bivariate Rate Ratio MI (95%CI)a |
P-valueb | Adjusted Rate Ratio for MI (95%CI)c |
Bivariate Rate Ratio CHD (95%CI)a |
P-valueb | Adjusted Rate Ratio for CHD (95%CI)c |
|---|---|---|---|---|---|---|---|---|---|
| Thymic Irradiation | < 0.001 | > 0.50 | 0.29 | ||||||
| Yes | 100 | – | 1.08 (0.82–1.42) | 0.98 (0.74–1.30) | 1.17 (0.94–1.39) | 1.07 (0.86–1.32) | |||
| No | – | 100 | Ref | Ref | |||||
| Sex | < 0.001 | < 0.001 | < 0.001 | ||||||
| Male | 57.9 | 50.7 | 2.75 (2.03–3.78) | 1.97 (1.44–2.72) | 2.68 (2.13–3.41) | 1.88 (1.48–2.40 | |||
| Female | 42.1 | 49.3 | Ref | Ref | |||||
| Attained Aged (years, mean) | 57.5 | 57.5 | 1.00 |
1.11 (1.10–1.12) Per decade |
< 0.001 | 1.12 (1.11–1.13) | < 0.001 | 1.10 (1.09–1.11) | |
| Smokee | 0.58 | < 0.001 | < 0.001 | ||||||
| Ever | 52.6 (1397) | 51.8 (2504) | 1.79 (1.32–2.48) | 1.49 (1.09–2.07) | 1.77 (1.39–2.28) | 1.41 (1.10–1.82) | |||
| Unknown | 13.2 (350) | 13.5 (651) | |||||||
| Never | 34.2 (909) | 34.7 (1678) | Ref | Ref | |||||
| Diabetesf | 0.49 | < 0.001 | < 0.001 | ||||||
| Yes | 11.1 (145) | 10.2 (181) | 3.43 (2.39–4.84) | 1.80 (1.24–2.59) | 3.27 (2.44–4.32) | 1.80 (1.34–2.39) | |||
| Unknown | 0.4 (5) | 0.2 (4) | |||||||
| No | 88.6 (1154) | 89.5 (1583) | Ref | Ref | |||||
| Dyslipidemiaf | 0.10 | < 0.001 | < 0.001 | ||||||
| Yes | 54.6 (712) | 51.7 (914) | 6.42 (3.99–11.04) | 4.04 (2.48–7.01) | 6.16 (4.23–9.34) | 4.01 (2.78–6.24) | |||
| Unknown | 0.4 (5) | 0.3 (5) | |||||||
| No | 45.0 (586) | 48.0 (849) | Ref | Ref | |||||
| Hypertensionf | 0.57 | < 0.001 | < 0.001 | ||||||
| Yes | 40.4 (527) | 39.4 (698) | 3.96 (2.76–5.80) | 2.11 (1.45–3.13) | 4.06 (3.04–5.50) | 2.29 (1.70–3.13) | |||
| Unknown | 0.5 (6) | 0.6 (10) | |||||||
| No | 59.1 (770) | 60.0 (1060) | Ref | Ref | |||||
| Family history MI or sudden deathf | 0.14 | 0.001 | NS | < 0.001 | NS | ||||
| Yes | 21.9 (285) | 24.2 (429) | 1.78 (1.25–2.52) | 1.66 (1.25–2.19) | |||||
| Unknown | 19.0 (248) | 17.6 (311) | |||||||
| No | 59.1 (770) | 58.1 (1027) | Ref | Ref | |||||
| Hypothyroide | 0.003 | 0.50 | – | < 0.001 | NS | ||||
| Yes | 4.3 (114) | 3.0 (146) | 1.06 (0.52–1.89) | 1.18 (0.71–1.85) | |||||
| Unknown | 15.3 (407) | 14.3 (689) | |||||||
| No | 80.3 (2135) | 82.7 (3998) | Ref | Ref |
Bolded p-values are for univariate comparisons that are potentially significant and thus tested in building multivariate models
a Relative risk and 95% CI in this column calculated separately for each variable in Poisson regression model stratified by attained age and sex. Sex evaluated in a model adjusted by attained age only
bp-value for likelihood ratio test for model fit compared to model with attained age and sex only
cAdjusted rate ratios for variables from most parsimonious multivariate Poisson regression model stratified by attained age and sex
dAt time of last follow-up
eVariable information collected on past surveys as well as 2004–08 survey
fVariables information only collected in 2004–2008 survey so numbers are for respondents to most recent survey only
-- Not significant in univariate analysis by treatment group or outcome status so placement in multivariate model not attempted
NS Potentially significant in univariate analysis stratified by attained age and sex (when appropriate), but does not add significantly to model as determined by Likelihood ratio test versus most parsimonious model