Table 3.

Main outcomes of studies on Internet-or mobile-based interventions for mental health problems.

Study	Health condition	Comparison	Main outcome [Instrument]	Outcomea [follow-up]b	95% CI
Bauer et al. (2012)	Bulimia Nervosa	Guided text messaging intervention vs. TAU	Remission rates [LIFE]	RR = 1.42c [8 months]	0.99; 2.02
Fichter et al. (2012)	Anorexia Nervosa (AN)	Internet-based guided self- help vs. TAU	Body Mass Index [BMI]	d = −0.19d [9 months]	−0.08; 0.46
Gulec et al. (2014)	Bulimia Nervosa/EDNOS	Internet-based guided self-help vs. TAU	Severity of eating disorder [EDE-Q]	d = −0.28d [4 months]	−0.73; 0.18
Jacobi et al. (2017)	Bulimia Nervosa (BN)	Internet-based guided self- help vs. TAU	abstinence from core symptoms of BN [SIAB-EX]	OR = 1.29 [9 months] OR = 1.49 [18 months]	0.68; 2.44 0.77; − 2.86
Holländare et al. (2011)	Depression	Internet-based guided self- help vs. TAU	Relapse rates [SCID]	RR = 0.28 [6 months] RR = 0.24 [24 months]e	0.10; 0.77 0.10; 0.55
Kordy et al. (2016)	Recurrent depression	Internet-based guided intervention vs. unguided intervention vs. TAU	Transition from to ‘well’ to ‘unwell’ [LIFE]	unguided: RR = 0.91 [12 months] RR = 0.69 [24 months] guided: RR = 1.11 [12 months] RR = 0.92 [24 months]	0.51; 1.64 0.44; 1.09 0.63; 1.95 0.59; 1.43
Kraft et al. (2017)	Depression	Text message self-help vs. TAU	Severity of depressive symptoms [PHQ-9]	d = −0.45 [4 months]	−1.11; −0.23
Norlund et al. (2018)	Myocardial Infarction (comorbid depressive/anxiety symptoms)	Web-based guided self- help vs. TAU	Severity of depression and anxiety [HADS-T]	d = −0.13 [14 weeks]	−0.38; 0.13
Schmädeke and Bischoff (2015)	Depression	Mobile-based self-help vs. TAU	Severity of depression symptoms [BDI]	d = −0.08 [3 months]	−0.49; 0.33
Zwerenz et al. (2017a)	Depression	Web-based self-help vs. attention control website	depressive symptoms [BDI-II]	d = −0.44 [6 months]	−0.71; −0.17
Bischoff et al. (2013)	Transdiagnostic	Mobile-based self-help vs. phone contact	Work-related Behaviour and Experience Patterns [AVEM]	d = 0.18 [6 months] d = 0.08 [12 months]	−0.21; 0.56 −0.32; 0.48
Ebert et al. (2013)	Transdiagnostic	Web-based guided self- help vs. TAU	general psychopathological symptom severity [HEALTH-49]	d = −0.38c [3 months] d = −0.44c [12 months]	−0.18; −0.58 −0.64; −0.24
Välimäki et al. (2017)	Transdiagnostic	Text message self-help vs. TAU	patient readmission to psychiatric hospital [Finnish national Care Register for Health Care (HILMO)]	RR = 1.11 [12 months]	0.92; 1.33
Willems et al. (2017a)	Cancer (transdiagnostic)	Web-based self-help vs. WLCG+TAU	Various, e.g. depression [PHQ-9]	d = −0.21 [6 months] d = −0.10 [12 months]f	−0.40; −0.01 −0.30; 0.11
Zwerenz et al. (2017b)	Transdiagnostic	Web-based guided self-help vs. WLCG	Various, e.g. depression [PHQ-9]	d = −0.34c [10 weeks]	−0.81; 0.14
Zwerenz et al. (2017a)	Transdiagnostic	Web-based guided self-help vs. TAU	subjective prognosis of work ability [SPE]	d = −0.13 [3 months] d = −0.20 [12 months]	−0.28; 0.03 −0.36; −0.04

Note. Own calculations based on study data. EDNOS: Eating disorder not otherwise specified; OR: Odd's ratio; RR: Risk ratio; TAU: Treatment as usual; WLCG: Waitlist control group. Abbreviations of measurement instruments can be found in Appendix D.

Note. Own calculations based on study data. EDNOS: Eating disorder not otherwise specified; OR: Odd's ratio; RR: Risk ratio; TAU: Treatment as usual; WLCG: Waitlist control group. Abbreviations of measurement instruments can be found in Appendix D.

^aBetween-group comparisons.

^bPost-treatment- and latest available follow-up.

^cITT-analyses.

^dUnpublished age stratified data provided by PI.

^eAdditional publication: Holländare et al. (2013).

^fAdditional publication: Willems et al. (2017b).