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. Author manuscript; available in PMC: 2019 Jul 6.
Published in final edited form as: Org Lett. 2018 Jun 25;20(13):4144–4147. doi: 10.1021/acs.orglett.8b01776

Scheme 2.

Scheme 2.

Analysis of alcohol configurations using the competing enantioselective conversion (CEC) method.a

aParallel acylation reaction were run with (R)- or (S)-HBTM catalyst (10 mol %), DIPEA (300 mol %) and propionic anhydride (300 mol %) at room temperature. The conversions were analyzed by 1H NMR after 1560 min. With the directing group to the left, faster reactions with the (R)HBTM indicate that the alcohol configuration is forward. See Supporting Information for more details. b0 °C, HBTM (26 mol %).