Figure 1.

Survey of AAV NAbs in Large Animals

Stacked histogram showing the distribution of (A) rhesus macaque, (B) cynomolgus macaque, (C) marmoset, chimpanzee, dog, and sheep serum samples harboring different levels of AAV NAbs as determined by an in vitro transduction inhibition assay (see Materials and Methods for assay details). Samples are categorized by the AAV NAb titer that is presented on a gray scale. Each stacked bar represents the test results for an individual AAV serotype. The AAV serotype, number of animals tested for each serotype (N), and percentage of NAb-negative samples (Neg%; defined as NAb titer <1:5) are labeled for each bar.