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Gene Therapy Using Engineered CD8+ T Cells
(A) CD8+ T cells are modified to express HIV-specific TCRs or CARs. Upon recognition of an infected cell, gene-modified CD8+ T cells mediate the destruction of the infected cell. (B) Examples of HIV-specific CARs. The structure of the TCR/CD3 complex with co-stimulatory receptors CD28 and 4-1BB is shown in the left panel. The structure of HIV-specific CARs is depicted in the right panel.
