Figure 4. Deletion of Trem1 decreases liver injury at early stages of liver fibrogenesis.

WT and Trem1^–/– mice were analyzed 6 hours, 12 hours, and 72 hours after injection of a single dose of CCl₄. Serum ALT (A–C) and AST (D–F) levels for the indicated mice were measured with colorimetric assay (n = 3–10 mice/time point/group). Results are displayed as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001, by 2-tailed Student’s t test.