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. 2018 Oct 2;128(11):4843–4855. doi: 10.1172/JCI95945

Figure 10. Effect of TREK-1 on cardiac remodeling and function.

Figure 10

Working model of TREK-1’s influence on cardiac morphology and function. Under normal conditions (left side), pressure overload stimulates TREK-1–mediated JNK phosphorylation, which both inhibits concentric hypertrophy and activates fibroblast function, resulting in cardiac dysfunction. In TREK-1 KO (right panel), pressure overload–mediated JNK phosphorylation is inhibited, resulting in enhanced concentric hypertrophy and reduced fibroblast function that is overall cardioprotective.