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. 2018 Oct 2;128(11):4843–4855. doi: 10.1172/JCI95945

Figure 7. Global TREK-1 KO alters JNK phosphorylation.

Figure 7

(A) Immunoblotting results for phosphorylated JNK (phospho-JNK) and the downstream JNK target, c-Jun, in WT and TREK-1–KO 3-day and 14-day TAC hearts. Representative array blots shown in the lower panel. (B) Immunoblotting results for phosphorylated JNK in WT and TREK-1–KO hearts harvested after either a perfusion control (PC) or ex vivo stretch (Str). Representative array blots shown in the lower panel. Data for WT sham or perfusion control conditions, which have a theoretical mean of 1, were compared with Wilcoxon’s signed rank test. *P < 0.05 versus perfusion control condition of the same genotype. Data for all other groups excluding the perfusion control condition were compared by Kruskal-Wallis test with Dunn’s multiple comparisons test. †P < 0.05 versus WT TAC. Full, uncut gels are shown in the supplemental material.