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. 2018 Oct 5;115(43):11042–11047. doi: 10.1073/pnas.1806376115

Fig. 1.

Fig. 1.

Mice are protected from cerebral malaria by 2DG. (A) Food intake was measured in C57BL/6J males infected with PbA (three cages of five mice housed per cage). (B) Kaplan–Meier plot of mice of the indicated genotype or diet (n = 5 per group). B6, C57BL/6J; KO, knockout; Ppara, PPAR-α. (C) Kaplan–Meier plot of mice treated with 2DG (200 mg/kg per injection), glucose (1 mg/kg per injection), or PBS beginning 8 h after infection and then given twice daily (n = 10 per group; PBS vs. 2DG: P = 0.002). (D) Clinical score of PbA-infected mice treated with 2DG or PBS (n = 5 per group; ***P < 0.0001 on days 9, 11, and 13). (E) Kaplan–Meier plot of mice treated with 2DG, 2DG followed by chloroquine (1 mg/mouse/d) on day 10 (D10), or chloroquine alone starting from D1 (n = 5 per group; P < 0.001 2DG vs. 2DG + chloroquine).