Fig. 4.

Microthrombi formation and hemostasis are affected by 2DG. (A) Representative section of PbA-infected animals treated with PBS or 2DG harvested on day 10 postinfection. (B) Quantification of thrombotic areas in serial sections of whole brain obtained from three PbA-infected animals receiving PBS or 2DG harvested on day 10 postinfection. ***P < 0.0009. TEG analyses of freshly citrated whole blood in PbA or sham-infected animals treated with PBS or 2DG harvested on day 10 postinfection, percentage of clot lysed after 30 min (C; Ly30) and maximum amplitude (MA; D) (Left), with representative tracings (Right) (n > 3 mice per group; *P < 0.05, **P < 0.006 by ANOVA).