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Models depicting the regulation of Srs2 on Rad51- and Dmc1-containing meiotic HR intermediates. (A) During meiosis, Srs2 is unable to effectively disrupt Dmc1-containing intermediates, which is anticipated to favor cross-over recombination outcomes. (B) Meiotic intermediates that are bound only by Rad51 would remain susceptible to the antirecombinase activity of Srs2 and would be channeled through the SDSA pathway.
