Table 1.

Regional HRF-PL results and correlation of HRF-PL with cortisol response and polygenic differences in the transcriptional response to GR activation (PGS)

Cluster no.*	FreeSurfer location†	Mean HRF-PL (SD)		Correlation‡ of HRF-PL with cortisol AUCcorr		Correlation‡ of HRF-PL with PGS
		Prestress	Stress	Prestress	Stress Δ	Prestress	Stress Δ
1	R insula	5.171 (0.601)	5.722 (0.392)	n.s.	n.s.	0.432 (0.008)	n.s.
2	R IFG (pars triangularis)	5.055 (0.577)	5.498 (0.557)	n.s.	n.s.	n.s.	n.s.
3	L IFG (pars triangularis)	5.129 (0.620)	5.390 (0.730)	n.s.	n.s.	n.s.	n.s.
	L insula	5.017 (0.576)	5.544 (0.491)	n.s.	0.375 (0.019)	0.394 (0.018)	−0.351 (0.036)
4	L insula	5.017 (0.576)	5.544 (0.491)	n.s.	0.375 (0.019)	0.394 (0.018)	−0.351 (0.036)
	L STG	5.349 (0.551)	5.630 (0.454)	−0.349 (0.029)	n.s.	0.402 (0.015)	n.s.
5	R amygdala	5.439 (0.739)	5.922 (0.616)	n.s.	n.s.	n.s.	n.s.
	R hippocampus	5.470 (0.738)	5.707 (0.493)	−0.493 (0.001)§	0.458 (0.003)§	0.538 (7e-4)§	−0.373 (0.025)
	R putamen	5.604 (0.800)	5.970 (0.634)	−0.353 (0.027)	0.323 (0.045)	0.457 (0.005)	n.s.
6	L hippocampus	5.404 (0.605)	5.774 (0.510)	−0.287 (0.080)	n.s.	0.306 (0.070)	n.s.
7	L SFG	5.060 (0.418)	5.418 (0.226)	n.s.	n.s.	n.s.	n.s.
8	L IFG (pars opercularis)	5.830 (0.716)	5.271 (0.627)	n.s.	n.s.	n.s.	n.s.

IFG, inferior frontal gyrus; ITG, inferior temporal gyrus; L, left hemispheric location; n.s., not significant; R, right hemispheric location; SFG, superior frontal gyrus; STG, superior temporal gyrus; Stress Δ, stress – prestress.

^*Cluster number according to SPM results as tabulated in SI Appendix, Table S1.

^†Corresponding cortical regions according to FreeSurfer parcellation. Note the double appearance of left insula that overlaps with clusters no. 3 and no. 4.

^‡Pearson r (P values).

^§Robust to Bonferroni correction for 11 regions.