Table 2:

Change in medication treatment adherence, bipolar symptoms, and functioning

Variable*	Screening*	Baseline	10-weeks	14 weeks	26 weeks	Statistic**
	Mean (SD)	Mean (SD)	Mean (SD)	Mean (SD)	Mean (SD)
Adherence
TRQ Past week						p= 0.001
CAE	55.4 (28.2)	43.0 (31.3)	25.7 (29.4)	33.7 (34.5)	20.7 (29.0)
EDU	55.0 (28.4)	45.4 (31.1)	35.0 (31.3)	31.7 (32.1)	30.3 (31.5)
TRQ Past month						p= 0.048
CAE	46.9 (28.8)	43.8 (27.4)	24.5 (28.2)	30.1 (32.0)	21.0 (28.2)
EDU	49.1 (28.3)	43.1 (30.3)	33.5 (28.7)	27.3 (27.3)	25.3 (25.8)
Symptoms
BPRS						p= 0.491
CAE	36.1 (6.9)	34.4 (7.7)	31.3 (6.3)	31.2 (6.9)	31.6 (7.1)
EDU	37.4 (8.3)	34.8 (7.8)	32.8 (7.3)	32.0 (7.4)	31.2 (7.7)
YMRS						p= 0.443
CAE	9.5 (5.1)	8.1 (4.8)	8.1 (5.5)	7.2 (5.1)	7.7 (6.2)
EDU	9.2 (5.2)	8.0 (5.4)	8.2 (5.1)	7.9 (5.2)	8.7 (5.9)
MADRS						p= 0.522
CAE	19.3 (8.2)	17.9 (8.9)	14.0 (7.8)	14.3 (9.3)	13.0 (8.4)
EDU	19.9 (9.3)	18.2 (8.6)	14.3 (9.6)	14.3 (10.0)	15.0 (10.9)
CGI						p= 0.910
CAE	N/A	3.4 (1.0)	3.2 (1.1)	2.9 (1.1)	3.0 (1.2)
EDU		3.4 (1.0)	3.1 (1.2)	3.1 (1.2)	3.0 (1.5)
GAF
CAE		59.4 (8.7)	63.6 (9.6)	63.9 (9.8)	65.8 (11.5)	p= 0.107***
EDU	N/A	59.5 (8.5)	61.3 (10.8)	61.3 (9.9)	62.1 (12.1)

Values are unadjusted means

^*Screening visit did not assess CGI, GAF

^**p-value refers to the group by time interaction using linear mixed effects analyses, except for TRQ past week and past month. These p-values are based on generalized linear mixed models with longitudinal binary outcomes (<= 20% non-adherent or not). Models were adjusted for gender, age, race, and marital status.

^***Comparison between baseline and 6-month GAF p =.03