Table 1. Echocardiography of WT and AR-null mice after 1 and 2 weeks of sham and TAC surgery.
Sham | 1 week | TAC | 1 week | Sham | 2 weeks | TAC | 2 weeks | |
---|---|---|---|---|---|---|---|---|
WT | AR-null | WT | AR-null | WT | AR-null | WT | AR-null | |
LVI Dd (mm) | 3.87±0.01 | 3.75±0.09 | 3.56±0.05 | 3.60±0.06 | 3.69±0.06 | 3.81±0.12 | 3.80±0.05 | 3.87±0.08 |
LVI Ds (mm) | 2.29±0.53 | 2.18±0.13 | 2.35± 0.15 | 2.68±0.89 | 2.22±0.07 | 2.27±0.14 | 2.42±0.09 | 2.70±0.11 |
End o EDV | 50±6 | 42±5 | 40±2 | 41±2 | 42±1 | 45±3 | 45±1 | 47±2 |
End o ESV | 15±3 | 11±3 | 17±2 | 19±3 | 13±1 | 15±2 | 18±2 | 23±2 |
EF (%) | 70±3 | 73±2 | 58±5 | 54±5*$ | 68±1 | 67±3 | 64±2 | 53±3*$# |
Heart rate | 566±16 | 511±20 | 518±14 | 518±15 | 474±6 | 480±6 | 495±6 | 491±6 |
SV | 35±3 | 31±4 | 23±3 | 19±2 | 29±1 | 29±2 | 27±1 | 24±1 |
CO | 19.48±1.55 | 15.48±0.43 | 12.95±1.07 | 11.37±0.79 | 13.81±0.51 | 14.22±1.14 | 13.45±0.47 | 11.88±0.52# |
p<0.05 vs WT sham
p<0.05 vs WT TAC
p<0.05 vs AR-null sham.