Table 2.
HRs (95% CI) of incident stroke according to quartiles of baseline hematocrit
| Q1 | Q2 | Q3 | Q4 | Q5 | P for trend | |
|---|---|---|---|---|---|---|
|
| ||||||
| Stroke, n (%) | 747 (4.05) | 709 (3.83) | 694 (3.73) | 751 (3.91) | 706 (3.81) | |
| Crude HR (95% CI) | 1.0 | 0.99 (0.89–1.10) | 1.00 (0.90–1.11) | 1.08 (0.97–1.20) | 1.07 (0.96–1.19) | 0.08 |
| Model 1 HRa (95% CI) | 1.0 | 1.16 (1.04–1.28) | 1.25 (1.12–1.39) | 1.40 (1.26–1.55) | 1.50 (1.34–1.67) | <0.001 |
| Model 2 HRb (95% CI) | 1.0 | 1.08 (0.97–1.20) | 1.13 (1.01–1.25) | 1.21 (1.09–1.35) | 1.25 (1.12–1.39) | <0.001 |
| Model 3 HRc (95% CI) | 1.0 | 1.05 (0.95–1.17) | 1.09 (0.98–1.21) | 1.16 (1.04–1.29) | 1.17 (1.04–1.31) | 0.0016 |
| Ischemic stroke, n (%) | 582 (3.15) | 563 (3.04) | 557 (2.99) | 625 (3.26) | 554 (2.99) | |
| Crude HR (95% CI) | 1.0 | 1.01 (0.90–1.32) | 1.03 (0.92–1.16) | 1.16 (1.03–1.30) | 1.08 (0.95–1.22) | 0.04 |
| Model 1 HRa (95% CI) | 1.0 | 1.19 (1.06–1.34) | 1.31 (1.16–1.47) | 1.53 (1.36–1.72) | 1.54 (1.36–1.75) | <0.001 |
| Model 2 HRb (95% CI) | 1.0 | 1.11 (0.99–1.25) | 1.18 (1.05–1.33) | 1.32 (1.17–1.48) | 1.28 (1.13–1.45) | <0.001 |
| Model 3 HRc (95% CI) | 1.0 | 1.09 (0.96–1.22) | 1.14 (1.01–1.28) | 1.25 (1.11–1.41) | 1.19 (1.05–1.35) | <0.001 |
| Intracerebral hemorrhage, n (%) | 170 (0.92) | 143 (0.77) | 143 (0.77) | 140 (0.73) | 147 (0.79) | |
| Crude HR (95% CI) | 1.0 | 0.88 (0.70–1.10) | 0.90 (0.72–1.12) | 0.87 (0.69–1.10) | 1.00 (0.79–1.26) | 0.88 |
| Model 1 HRa (95% CI) | 1.0 | 0.99 (0.79–1.24) | 1.07 (0.85–1.34) | 1.07 (0.85–1.35) | 1.30 (1.03–1.64) | 0.04 |
| Model 2 HRb (95% CI) | 1.0 | 0.93 (0.75–1.17) | 0.97 (0.77–1.22) | 0.94 (0.75–1.19) | 1.11 (0.87–1.41) | 0.49 |
| Model 3 HRc (95% CI) | 1.0 | 0.93 (0.74–1.16) | 0.96 (0.76–1.21) | 0.93 (0.73–1.17) | 1.08 (0.85–1.38) | 0.61 |
| Sensitivity analysisd | 1.0 | 1.05 (0.94–1.16) | 1.10 (0.99–1.23) | 1.17 (1.05–1.30) | 1.17 (1.04–1.31) | 0.0011 |
Notes:
a
Model 1: adjusted for age and sex.
b
Model 2: adjusted for age, sex, smoking, drinking, body mass index, hypertension, diabetes mellitus and dyslipidemia.
c
Model 3: adjusted for age, sex, smoking, drinking, body mass index, hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, SBP, FPG, TC, LDL and estimated glomerular and proteinuria.
d
Adjusted for model 3 and further excluded individuals who developed hypertension during the follow-up.
Abbreviations: FPG, fasting plasma glucose; LDL, low-density lipoprotein; TC, total cholesterol; Q, quintile.