Table 2.
Univariate and multivariate analyses of progression-free survival in bladder cancer patients
| Variable | Univariate analyses HR (95% CI) | P-value | Multivariate analyses HR (95% CI) | P-value |
|---|---|---|---|---|
|
| ||||
| Age | ||||
| ≤65 years | 1 | 0.155 | ||
| >65 years | 1.428 (0.873–2.335) | |||
| BMI | ||||
| <24 | 1 | 0.904 | ||
| ≥24 | 0.970 (0.590–1.594) | |||
| Gender | ||||
| Male | 1 | 0.125 | ||
| Female | 0.518 (0.224–1.201) | |||
| Smoking history | ||||
| No | 1 | <0.001 | 1 | <0.001 |
| Yes | 4.757 (2.751–8.225) | 4.128 (2.332–7.305) | ||
| Hypertension | ||||
| No | 1 | 0.779 | ||
| Yes | 1.083 (0.622–1.883) | |||
| Diabetes mellitus | ||||
| No | 1 | 0.167 | ||
| Yes | 1.523 (0.839–2.766) | |||
| Cardiovascular disease | ||||
| No | 1 | 0.337 | ||
| Yes | 0.781 (0.472–1.294) | |||
| Histology type | ||||
| Transitional cell carcinoma | 1 | 0.68 | ||
| Non-transitional cell carcinoma | 1.153 (0.587–2.263) | |||
| Grade | ||||
| 1 and 2 | 1 | 0.169 | ||
| 3 | 1.803 (.778–4.178) | |||
| T-stage | ||||
| NMIBC | 1 | <0.001 | 1 | 0.003 |
| MIBC | 3.797 (2.141–6.736) | 2.445 (1.345–4.443) | ||
| N-stage | ||||
| Negative | 1 | 0.028 | – | – |
| Positive | 2.139 (1.084–4.223) | |||
| M-stage | ||||
| Negative | 1 | 0.198 | ||
| Positive | 1.951 (0.706–5.389) | |||
| ASA grade | ||||
| 1 and 2 | 1 | 0.033 | 1 | 0.043 |
| 3 and 4 | 2.167 (1.065–4.409) | 2.128 (1.025–4.416) | ||
| NLR | ||||
| ≤3.8 | 1 | 0.155 | ||
| >3.8 | 1.453(0.868–2.432) | |||
| PLR | ||||
| ≤210.9 | 1 | 0.206 | ||
| >210.9 | 1.525 (0.793–2.934) | |||
| PNI | ||||
| ≤38.5 | 1 | 0.006 | – | – |
| >38.5 | 0.426 (0.231–0.786) | |||
| CAR | ||||
| ≤0.2 | 1 | <0.001 | 1 | 0.012 |
| >0.2 | 2.401 (1.473–3.916) | 1.893 (1.150–3.114) | ||
Note: P-values <0.05 are shown in bold.
Abbreviations: ASA, American Society of Anesthesiologists; BMI, body mass index; CAR, C-reactive protein/albumin ratio; MIBC, muscle-invasive bladder cancer; NLR, neutrophil-to-lymphocyte ratio; NMIBC, non-muscle invasive bladder cancer; PLR, platelet-to-lymphocyte ratio; PNI, prognostic nutritional index.