Table 3.
Univariate and multivariate analyses of overall survival in bladder cancer patients
| Variable | Univariate analyses HR (95% CI) | P-value | Multivariate analyses HR (95% CI) | P-value |
|---|---|---|---|---|
|
| ||||
| Age | ||||
| ≤65 years | 1 | 0.01 | – | – |
| >65 years | 1.958 (1.175–3.354) | |||
| BMI | ||||
| <24 | 1 | 0.277 | ||
| ≥24 | 0.747 (0.442–1.264) | |||
| Gender | ||||
| Male | 1 | 0.504 | ||
| Female | 0.764 (0.347–1.681) | |||
| Smoking history | ||||
| No | 1 | <0.001 | 1 | <0.001 |
| Yes | 5.046 (2.800–9.093) | 4.169 (2.218–7.835) | ||
| Hypertension | ||||
| No | 1 | 0.323 | ||
| Yes | 1.365 (0.736–2.531) | |||
| Diabetes mellitus | ||||
| No | 1 | 0.702 | ||
| Yes | 1.118 (0.632–1.978) | |||
| Cardiovascular disease | ||||
| No | 1 | 0.542 | ||
| Yes | 0.851 (0.507–1.429) | |||
| Histology type | ||||
| Transitional cell carcinoma | 0.44 | |||
| Non-transitional cell carcinoma | 1.295 (0.673–2.492) | |||
| Grade | ||||
| 1 and 2 | 1 | 0.295 | ||
| 3 | 1.569 (0.675–3.647) | |||
| T-stage | ||||
| NMIBC | 1 | <0.001 | 1 | 0.001 |
| MIBC | 6.084 (2.983–12.408) | 3.361 (1.601–7.055) | ||
| N-stage | ||||
| Negative | 1 | 0.018 | – | – |
| Positive | 2.221 (1.147–4.301) | |||
| M-stage | ||||
| Negative | 1 | 0.018 | 1 | 0.006 |
| Positive | 3.035 (1.208–7.625) | 4.006 (1.494–10.742) | ||
| ASA grade | ||||
| 1 and 2 | 1 | 0.013 | – | – |
| 3 and 4 | 2.385 (1.204–4.724) | |||
| NLR | ||||
| ≤3.8 | 1 | <0.001 | – | – |
| >3.8 | 2.754 (1.655–4.584) | |||
| PLR | ||||
| ≤210.9 | 1 | 0.01 | – | – |
| >210.9 | 2.248 (1.212–4.167) | |||
| PNI | ||||
| ≤38.5 | 1 | 0.002 | – | – |
| >38.5 | 0.380 (0.208–0.692) | |||
| CAR | ||||
| ≤0.2 | 1 | <0.001 | 1 | <0.001 |
| >0.2 | 4.214 (2.500–7.102) | 3.063 (1.788–5.249) | ||
Note: P-values <0.05 are shown in bold.
Abbreviations: ASA, American Society of Anesthesiologists; BMI, body mass index; CAR, C-reactive protein/albumin ratio; MIBC, muscle-invasive bladder cancer; NLR, neutrophil-to-lymphocyte ratio; NMIBC, non-muscle invasive bladder cancer; PLR, platelet-to-lymphocyte ratio; PNI, prognostic nutritional index.