Table 4.

Distribution of CYP2D6 metabolizer phenotypes in the two groups studied according to sex

	WT/EM	IM/PM	UM	Total
Males	55 (83.3%)	10 (15.2%)	1 (1.5%)	66
Case	6 (85.7%)	–	1 (14.3%)	7
Control	49 (83.1%)	10 (17.0%)		59
Females	101 (77.7%)	23 (17.7%)	6 (4.6%)	130
Case	15 (75.0%)	4 (20.0%)	1 (5.0%)	20
Control	86 (78.2%)	19 (17.3%)	5 (4.6%)	110
Total	156 (79.6%)	33 (16.8%)	7 (3.6%)	196

Note: No significant differences between sexes were found (Case, Fisher’s exact test P=0.304; Control, Fisher’s exact test P=0.302).

Abbreviations: EM, extensive metabolizer; IM, intermediate metabolizer; PM, poor metabolizer; UM, ultrarapid metabolizer.