Table 4.
Distribution of CYP2D6 metabolizer phenotypes in the two groups studied according to sex
| WT/EM | IM/PM | UM | Total | |
|---|---|---|---|---|
|
| ||||
| Males | 55 (83.3%) | 10 (15.2%) | 1 (1.5%) | 66 |
| Case | 6 (85.7%) | – | 1 (14.3%) | 7 |
| Control | 49 (83.1%) | 10 (17.0%) | 59 | |
|
| ||||
| Females | 101 (77.7%) | 23 (17.7%) | 6 (4.6%) | 130 |
| Case | 15 (75.0%) | 4 (20.0%) | 1 (5.0%) | 20 |
| Control | 86 (78.2%) | 19 (17.3%) | 5 (4.6%) | 110 |
|
| ||||
| Total | 156 (79.6%) | 33 (16.8%) | 7 (3.6%) | 196 |
Note: No significant differences between sexes were found (Case, Fisher’s exact test P=0.304; Control, Fisher’s exact test P=0.302).
Abbreviations: EM, extensive metabolizer; IM, intermediate metabolizer; PM, poor metabolizer; UM, ultrarapid metabolizer.