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. 2018 Oct 24;13:6699–6715. doi: 10.2147/IJN.S178809

Figure 2.

Figure 2

Body temperature and IAV titration in vaccinated and virus-challenged pigs.

Notes: Animals were vaccinated using liposome entrapped, ten influenza conserved peptide cocktail vaccine intranasally and challenged with a virulent SwIAV H1N1-OH7. (A) Graph showing the average rectal temperature recorded daily post-challenge infection. The dashed line at temperature 104°F indicates fever in pigs. Challenge SwIAV H1N1-OH7 titer in (B) nasal swab at DPC 4 and (C) BAL fluid at DPC 6. Temperature data were analyzed by repeated measure ANOVA using Friedman test followed by Dunn’s pairwise comparison. Virus titer data were analyzed by non-parametric Kruskal-Wallis test followed by Dunn’s post hoc test. Each bar represents the mean and SEM of 4–6 pigs. Asterisk refers to statistical difference between two indicated pig groups (*P<0.05 and **P<0.01).

Abbreviations: BAL, bronchoalveolar lavage; DPC, day post-challenge; IAV, influenza A virus; NPs, nanoparticles; SwIAV, swine influenza A virus; SEM, standard error of mean; TCID, tissue culture infective dose.