Table S2.

The combination effect and the expected additive effect PC-3

PC-3	Sorafenib(a)	2 mm	4 mm	6 mm	2 mm	4 mm	6 mm
Clofoctol (b)	Effect	0.106	0.228	0.257	Eab=Ea+(l-Ea)Eb
Dose (pM)	Effect	Combination effect			Expected effect
2	0.077	0.182	0.264	0.384	0.175	0.287	0.314
4	0.078	0.244	0.336	0.417	0.176	0.288	0.315
6	0.078	0.263	0.422	0.66	0.176	0.288	0.315
8	0.076	0.325	0.625	0.795	0.174	0.287	0.313
10	0.052	0.441	0.739	0.848	0.152	0.268	0.296
12	0.165	0.61	0.834	0.887	0.254	0.355	0.380
DUI45
Clofoctol (b)	effect	0.05	0.095	0.227	Eab=Ea+(l-Ea)Eb
Dose (pM)	effect	Combination effect			Expected effect
2	0.02	0.117	0.205	0.424	0.069	0.113	0.242
4	0.067	0.138	0.286	0.548	0.114	0.156	0.279
6	0.074	0.181	0.488	0.78	0.120	0.162	0.284
8	0.142	0.379	0.75	0.828	0.185	0.224	0.337
10	0.154	0.57	0.806	0.856	0.196	0.234	0.346
12	0.295	0.77	0.474	0.863	0.330	0.362	0.455
LNCaP
Clofoctol (b)	effect	0.206	0.37	0.756	Eab=Ea+(l-Ea)Eb
Dose (pM)	effect	Combination effect			Expected effect
2	0.075	0.305	0.541	0.883	0.266	0.417	0.774
4	0.1	0.438	0.731	0.917	0.285	0.433	0.780
6	0.279	0.697	0.903	0.934	0.428	0.546	0.824
8	0.455	0.856	0.93	0.958	0.567	0.657	0.867
10	0.615	0.931	0.935	0.96	0.694	0.757	0.906
12	0.83	0.948	0.959	0.961	0.865	0.893	0.959