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. 2018 Oct 29;13(10):e0199087. doi: 10.1371/journal.pone.0199087

Fig 4. Timing of waking behavior incidence varies with reversing agent, while order is generally maintained.

Fig 4

A) Animals that did not receive alpha receptor agonists or antagonists (ketamine+isoflurane+saline) notice the sticky dot earlier than animals from the saline (SAL) and yohimbine (YOH) group The Kruskal-Wallis test indicated a significant difference among groups (p = 0.0052, χ2: 14.79). The significant differences between the groups exclusive K/I-SAL (K/I: ketamine/isoflurane) are reported in the results section. Time to sticky dot notice for K/I-SAL was significantly shorter when compared to SAL, YOH. There was no significant difference when compared to the atipamezole (ATI) group The solid, gray lines indicate significant differences between groups. B) All measured waking behavior hallmarks compared between the groups. The gray line indicates time of reversal injection, 15 minutes post-ketamine/xylazine injection. The solid lines present the mean and the 95% confidence interval on the mean.