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. Author manuscript; available in PMC: 2018 Oct 29.
Published in final edited form as: Dalton Trans. 2015 Mar 21;44(11):4819–4844. doi: 10.1039/c4dt02846e

Figure 11.

Figure 11

Dual-modality (MRI/SPET) contrast agent combining iron oxide nanoparticles with 99mTc radiolabel linked to the inorganic iron oxide surface via bisphosphonate groups. Top: assembly of composite particle; bottom: Mouse images, transverse sections through liver. A: MR image pre-injection of contrast agent; B: MR image post-injection of contrast agent showing darkening of liver due to accumulation of iron oxide nanoparticles; C: SPET/CT image showing co-localisation of 99mTc with iron oxide contrast in liver (L) and spleen (S).