Table 3. Association with immunological failure, using a logistic regression model.
| Variable | Unadjusted/ univariate model |
Adjusted/ multivariate model |
|||
|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | ||
| CAA+ | 0.78 (0.39–1.59) | 0.50 | 0.71 (0.32–1.59) | 0.41 | |
| Age, per 10 years | 1.09 (0.85–1.39) | 0.51 | 1.04 (0.79–1.37) | 0.79 | |
| Female | 1.18 (0.66–2.12) | 0.58 | 0.75 (0.38–1.50) | 0.42 | |
| Body mass index (BMI), per kg/m2 |
1.00 (0.93–1.08) | 0.97 | 0.95 (0.86–1.04) | 0.28 | |
| Education lower vs. higher* | 0.22 (0.28–1.64) | 0.14 | 0.28 (0.04–2.21) | 0.23 | |
| CD4 cell count, per 25/μl | 1.08 (1.04–1.13) | <0.01 | 1.08 (1.03–1.13) | 0.02 | |
| Delay to CD4 testing** | 0.97 (0.95–1.00) | 0.07 | 0.98 (0.95–1.01) | 0.26 | |
| WHO-stage 3/4 vs. 1/2 | 0.87 (0.50–1.48) | 0.60 | 0.88 (0.45–1.71) | 0.71 | |
| Active tuberculosis | 0.63 (0.28–1.40) | 0.25 | 0.38 (0.14–1.05) | 0.06 | |
| MXD >1,100 cells/μl*** | 1.13 (0.62–2.07) | 0.68 | 1.10 (0.58–2.12) | 0.76 | |
| Constant | 3.35 (0.11–100.72) | 0.49 | |||
*Educational attainment: lower (none/primary) vs. higher than primary
**Delay to CD4 testing: median time from ART initiation to measurement of CD4 cell count in weeks
***MXD: cumulative value of eosinophils, basophils, and monocytes