Table 1.

Asynchronous pharmacokinetic profile of drug combinations typically used to treat chronic disease states.

					Asynchronous pharmacokinetic parameters
Disease indication	Drug	Log P	Dose	Regimen	Tmax	T1/2
HIV	Emtricitabine	−0.6	200 mg	PO QD	3 h	10 h
	Rilpivirine	4.5	25 mg	PO QD	4 h	50 h
	Tenofovir alafenamide	1.9	25 mg	PO QD	1 h	0.51 h
Cancer	Doxil (liposomal doxorubicin)	1.3	60 mg/m2	IV	–	55 h at 20 mg/m2
	Cyclophophamide	0.6	600 mg/m2	IV	–	3–12 h
Hepatitis C	Sofosbuvir	1	400 mg	PO QD	0.8–1 h (prodrug); 3.5–4 h (active)	0.4 h (prodrug); 27 h (active)
	Ledipasvir	7.4	90 mg	PO QD	4–4.5 h	47 h