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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: J Autoimmun. 2018 Feb 1;89:139–148. doi: 10.1016/j.jaut.2017.12.013

Figure 2. Treg-specific NKAP deletion results in lymphoproliferation and conventional T cell activation.

Figure 2

(A) Forward scatter and side scatter analysis of splenocytes from Foxp3-YFP-cre WT, Foxp3-YFP cre NKAP cKO and scurfy mice. (B) Analysis of frequency and absolute numbers of CD4 and CD8 T cells from spleens of Foxp3-YFP-cre WT, Foxp3-YFP-cre NKAP cKO and scurfy mice. (C) Analysis of frequency and absolute numbers of activated memory (CD44+ CD62L−) and naïve (CD44+ CD62L−) CD4+ and CD8+ T cells from spleens of Foxp3-YFP-cre WT, Foxp3-YFP-cre NKAP cKO and scurfy mice. All data shown are representative of at least 6 independent experiments with 6–7 mice in each group. Bar graphs illustrate mean absolute cell counts and error bars are SEM.