Table 2a.

Multivariable association between baseline markers of systemic inflammation and T1 mapping measures (Native T1mapping and Extracellular Volume Fraction in males (n=446)

Inflammatory Markers		ECV (%)		Native T1 (ms)
		Β-Coefficient (95% CI)	p-Value	Β-Coefficient (95% CI)	p-Value
Log IL6 ^* (pg/mL)	Model A	0.6 (0.1 – 1.0)	0.01	3.1 (−3.0–9.3)	0.32
Log IL6 ^* (pg/mL)	Model B	0.4 (0.01 – 0.9)	0.05	2.8 (−4.0–9.6)	0.42

Fibrinogen (mg/dL)	Model A	−0.0002 (−0.005–0.005)	0.94	−0.005 (−0.07–0.06)	0.88
Fibrinogen (mg/dL)	Model B	0.001 (−0.003–0.006)	0.61	0.01 (−0.06–0.08)	0.77

Log CRP ^* (mg/L)	Model A	0.07 (−0.2–0.4)	0.66	3.7 (−0.2–7.7)	0.06
Log CRP ^* (mg/L)	Model B	0.2 (−0.1–0.5)	0.23	4.9 (0.5–9.2)	0.03

CRP: C-Reactive Protein; ECV: Extracellular Volume fraction; IL6: Interleukin 6; CI: Confidence interval

CRP and IL6 had a right-skewed distribution leading to logarithmic transformation of these variables for this analysis

Model A is adjusted for age, race, body mass index, baseline cigarette smoking status, diabetes classification, systolic blood pressure, total cholesterol, high density lipoprotein, hypertension medication use and lipid lowering medication use, left ventricular ejection fraction, left ventricular mass index and end diastolic volume index at the time of the MRI exam in MESA 5

Model B: Model A and excluding those with myocardial scar using late gadolinium enhancement, history of myocardium infarction or clinical heart failure (n=372).