Table 1.
Patients | MUCH Definition | FU (years) | Events | Type of Event | |||
---|---|---|---|---|---|---|---|
Study | CH | MUCH | CH | MUCH | |||
OvA Study 20037 | 146 | 143 | Day BP≥135/85 mmHg | 5 | 7 | 9 | Fatal/Nonfatal CVE |
Chieti-Pescara Study 2005–201710,26 | 523 | 215 | Day BP≥135/85 mmHg | 10 | 79 | 69 | Fatal/Nonfatal CVE |
IDACO Study 2005–20179,12,13,15,18,19,23 | 528 | 236 | Day BP≥135/85 mmHg | 11 | 147 | 93 | Fatal/Nonfatal CVE |
Hadassah Study 200816 | 360 | 268 | Day BP≥135/85 mmHg | 7.7 | 23 | 29 | All-Cause Mortality |
Jackson Heart Study 201624 | 272 | 135 | Day BP≥135/85 mmHg | 8.2 | 16 | 22 | Fatal/nonfatal CVE |
Spanish Registry Study28 | 7406 | 2378 | Day BP≥135/85 mmHg | 4.7 | 273 | 166 | All-Cause Mortality |
BP, blood pressure; CH, controlled hypertension; CVE, cardiovascular events (stroke, coronary artery disease, heart failure and peripheral revascularization for OvA, Chieti-Pescara and IDACO Studies; stroke and coronary artery disease for Jackson Heart Study); FU, follow-up (mean); IDACO, International Database on Ambulatory blood pressure in relation to Cardiovascular Outcomes; MUCH, masked uncontrolled hypertension; OvA, Office versus Ambulatory pressure. Data of the OvA, IDACO, Hadassah and Spanish Registry Studies are provided by the authors. Data of the Chieti Pescara Study, provided by the authors, come from the overall database of treated hypertensive patients at baseline (2264 patients) which includes patients aged≥60 years reported in Ref. 26, those aged < 60 years reported in Ref. 10 and other patients aged < 60 years of the database (data of patients aged≥and < 60 years are equally updated to 2013); the cutoff of daytime BP to define MUCH was chosen for homogeneity with other studies. Data of the Jackson Heart Study are published data. Daytime BP recording interval: OvA Study (30 minutes), Chieti-Pescara Study (15 minutes), IDACO Study (15–30 minutes), Hadassah Study (20 minutes), Jackson Heart Study (20 minutes) and Spanish Registry Study (20 minutes).