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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Stroke. 2018 Oct;49(10):2453–2463. doi: 10.1161/STROKEAHA.118.021452

Figure 4. Post-stroke oligodendrogenesis is inhibited in db/db mice compared to WT mice and db/+ mice.

Figure 4.

BrdU and NG2 or APC double immunostaining was performed to detect oligodendrogenesis in the external capsule (EC) and cortex (CTX) of WT mice, db/+, mice and db/db mice 14d and 35d after dMCAO. A, Quantification of the number of BrdU and NG2 double-immunostained cells. n=6–10/group. B, Quantification of the number of BrdU and APC double-immunostained cells. n=5–10/group. Scale bar: 40 μM. **p<0.01, ***p<0.001, ****p<0.0001, WT vs. db/db; #p<0.05, ##p<0.01, ###p <0.001, db/+ vs. db/db; one-way ANOVA followed by Bonferroni post hoc. C, Pearson correlation between the number of NG2+ BrdU+ OPCs or APC+BrdU+ oligodendrocytes and MBP staining intensities in the EC or CTX 35d after dMCAO.