Skip to main content
. 2018 Sep 25;7:e36717. doi: 10.7554/eLife.36717

Figure 2. Effects of individual conductances on the Ca2+ transient (CaT).

Figure 2.

(A) CaT amplitude defined as the difference Δ[Ca]i between the peak and diastolic values of the cytosolic Ca2+ concentration [Ca]i versus G/Gref where G is the individual conductance value and Gref some fixed reference value. (B) Time-averaged [Ca]i over one pacing period ([Ca]i) versus G/Gref. Illustration of the effect of varying ICa,L conductance (C) and Ito,f conductance (D) on AP and CaT profiles, where 50%, 100%, and 150% correspond to Gref=0.5, 1.0, and 1.5, respectively. (E) Effect of varying RyR conductance on SR Ca2+concentration [Ca]SR and CaT. Different time windows are plotted for the CaT and SR load (0 to 150 ms) and AP waveforms (0 to 50 ms) in (C-–E).