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. 2018 Sep 25;7:e36717. doi: 10.7554/eLife.36717

Figure 7. Compensation and gene expression.

Figure 7.

Plot showing the existence of a statistically very significant correlation (Pearson correlation coefficient r=0.47 and p-value, p=8.11013) between the expression level of Kcnip2, encoding the KChIP2 accessory β subunits that interact with Kv4.2 channels (Ito,f) and of Cacna1c, a gene encoding the α1C subunit of the Cav1.2 L-type calcium channels (ICa,L) across 206 mice. Cardiac gene expression was measured in 106 control (Pre-ISO) strains and 21 days after injection of isoproterenol (post-ISO) in 100 HMDP strains (a smaller number due to higher mortality of certain strains). Note that the significant correlation holds when considering separately pre-ISO (blue points, r=0.59p=21011) and post-ISO (red points, r=0.42p=1.5105) data. Lines show best fits of a linear model for pre-ISO (blue), post-ISO (red), and pre- and post-ISO combined (black). Expression data is taken from Santolini et al. (2018) and is averaged over all microarray probes for each gene.