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. 2018 Sep 25;7:e36717. doi: 10.7554/eLife.36717

Table 4. Reference values of ionic current parameters varied in the GES search.

Parameter Definition Reference value Reference source

gCa

Ca2+ current flux 333.32 mmol/(Cm C) Measured

vup

Peak uptake rate 1.17 μM/ms Chosen*

gNaCa

Peak NaCa rate 36.6 μM/s Bondarenko et al., 2004

gRyR

Release current
strength
12.9 sparks cm2/mA Mahajan et al. (2008)

gto,f

Ito,f peak
conductance
0.16 A/F Measured

gKur

IKur peak
conductance
0.144 A/F Measured

*vup was chosen such that the reference Ca2+ transient amplitude was normal.