Figure 1.
Genome-wide Significant Genotype-Immune Phenotype Associations
(A) Circos plot demonstrating eight regions reaching genome-wide significant association with immune phenotypes. The y axis displays the negative logarithm of the p value. Variants reaching genome-wide significance (p < 5 × 10−8, dotted red line) are depicted in red, and the corresponding trait with which the variant is associated is indicated.
(B) Overview of the association of eight independent lead variants reaching genome-wide significance to at least one immune phenotype with all 54 immune phenotypes (see also Table S1 for definitions of immune phenotypes). Darkest colors indicate genome-wide significant associations, whereas red and blue colors distinguish a positive or negative direction of effect, respectively. Genome-wide (GW) significant, suggestive, nominal, and trend correspond to p values < 5 × 10−8, < 1 × 10−4, < 0.05, and < 0.10, respectively.