Figure 5.

Genetic Control of Pro-inflammatory Cytokine Production

(A) Regional association plot for ex vivo plasma interleukin-6 levels additionally depicting known GWAS hits in this region, including a variant associated with pediatric autoimmune diseases but in weak LD (r² = 0.055).

(B and C) Boxplot for ex vivo plasma interleukin-6 levels (B) and interleukin-6 gene expression (C) in RNA extracted from PBMCs (simplex measurements from 173 individuals) (p = 0.16). Additional legend as in Figure 2.