Table 1. Study protocol of included animal trials; HBOT − hyperbaric oxygen therapy; M – male; F − female; d – days; ATA − atmosphere absolute; CRT – chemoradiotherapy; CT – Chemotherapy; GH − growth hormone; BPR − bursting pressure; HP – hydroxyproline; PPg-glucan − poly B1-6 glucotriosys B1-3 glucopyranose glucan; PA − pathological analysis; MMP − matrix-metalloproteinase; BA − biochemical analysis; ETR − total energy of rupture biomechanical test .
| Author | n | Species/sex | Pre/postop HBOT | HBOT days/length (min)/pressure (kPa) | Additional interventions | Additional interventions | Measured outcomes |
| Boersema[4] | 10 | Wistar, M | Colectomy | Pre- and postop | 7 preop + 3 postop / 1 x 90 / 243 | None | BPR+PA |
| Hamzaoğlu[20] | 10 | Wistar, M | Left colon resection | Postoperative | 4 / 1 x 60 / 253 | Induced ischaemia | BPR+HP |
| Erenoglu[21] | 10 | Wistar, M | Colectomy | Postoperative | 7 / 2 x 90 / 203 | Preoperative CRT | BPR+HP |
| Guzel[22] | 10 | Wistar, F | Induced ischaemia + colonic anastomosis | Postoperative | 4 / 1 x 60 / 253 | PPg-glucan | BPR+HP |
| Yagci[23] | 10 | Wistar, M | Left colon resection | Preoperative | 2 / 2 x 90 / 284 | Induced ischaemia | BPR+HP+PA |
| Yagci[23] | 10 | Wistar, M | Left colon resection | Postoperative | 4 / 2 x 90 / 284 | Induced ischaemia | BPR+HP+PA |
| Yagci[23] | 10 | Wistar, M | Left colon resection | Pre- and postop | 2 preop + 4 postop / 2 x 90 / 284 | Induced ischaemia | BPR+HP+PA |
| Sucullu[24] | 8 | Wistar, M/F | Induced peritonitis + colectomy | Postoperative | 3 or 7 / 1 x 90 / 253 | None | BPR+HP+PA |
| Azevedoi[25] | 10 | Wistar, ? | Colectomy | Postoperative | 7 / 1 x 90 / 203 | Induced ischaemia | HP+MMP1+MMP9 |
| Rocha[26] | 15 | Wistar, F | Induced peritonitis + colectomy | Postoperative | 4 / 1 x 120 / 203 | None | ETR |
| Adas[27] | 10 | Wistar, M | Left colon resection | Postoperative | 4 / 3 x 60 / 253 | GH | BPR+PA |
| Kemik[28] | 10 | Wistar, F | Left colon resection | Postoperative | 4 / 4 x 80 / 253 | CT | BPR+PA |
| Yildiz[29] | 12 | Wistar, F | Left colon resection | Postoperative | 5 / 2 x 90 / unknown | Preoperative CRT | BPR+HP+PA |
| Poyrazoglu[30] | 7 | Sprague-Dawley, M | Left colon resection | Postoperative | 4 / 1 x 120 / 284 | None | BPR+BA |
| Poyrazoglu[30] | 7 | Sprague-Dawley, M | Left colon resection | Pre- and postop | 2 h preop + 4 postop / 1 x 120 / 284 | None | BPR+BA |
| Emir[31] | 10 | Wistar, M | Laparoscopic left colon resection | Postoperative | 10 / 1 x 60 / 213 | None | BPR+HP+PA |