Table 5. Diagnostic test characteristics of Hi-SNR MRI-C in diagnosing steatosis at different MRS-based PDFF cutoffs.

MRS-PDFF cutoff using equivalent MRI-C thresholds		Sensitivity (%) (95% CI)	Specificity (%) (95% CI)	PPV (%) (95% CI)	NPV (%) (95% CI)	Accuracy (%) (95% CI)
3%	Standard MRI-C	99.1 (96.7 – 99.9)	72.2 (58.4 – 83.5)	93.5 (89.5 – 96.3)	95.1 (83.5 – 99.4)	93.7 (90.1 – 96.3)
	Hi-SNR MRI-C	98.2 (95.3 – 99.5)	90.7 (79.7 – 96.9)	97.7 (94.7 – 99.3)	92.5 (81.8 – 97.9)	96.7 (93.8 – 98.5)
4%	Standard MRI-C	98.0 (94.9 – 99.4)	83.3 (72.7 – 91.1)	94.2 (90.1 – 97.0)	93.8 (84.8 – 98.3)	94.1 (90.6 – 96.6)
	Hi-SNR MRI-C	97.0 (93.6 – 98.9)	90.3 (81.0 – 96.0)	96.5 (92.9 – 98.6)	91.5 (82.5 – 96.8)	95.2 (91.9 – 97.4)
5%	Standard MRI-C	93.6 (89.1 – 96.6)	94.0 (86.7 – 98.0)	97.2 (93.6 – 99.1)	86.8 (78.1 – 93.0)	93.7 (90.1 – 96.3)
	Hi-SNR MRI-C	95.7 (91.7 – 98.1)	98.8 (93.5 – 100)	99.4 (96.9 – 100)	91.2 (83.4 – 96.1)	96.7 (93.8 – 98.5)
6%	Standard MRI-C	92.9 (87.9 – 96.3)	98.0 (93.1 – 99.8)	98.7 (95.5 – 99.8)	89.3 (82.0 – 94.3)	94.8 (91.5 – 97.1)
	Hi-SNR MRI-C	95.3 (90.9 – 97.9)	97.1 (91.6 – 99.4)	98.2 (94.7 – 99.6)	92.5 (85.8 – 96.7)	95.9 (92.9 – 98.0)
7%	Standard MRI-C	91.7 (86.3 – 95.5)	99.1 (95.2 – 100)	99.3 (96.2 – 100)	89.7 (83.0 – 94.4)	94.8 (91.5 – 97.1)
	Hi-SNR MRI-C	93.6 (88.6 – 96.9)	99.1 (95.2 – 100)	99.3 (96.3 – 100)	91.9 (85.6 – 96.0)	95.9 (92.9 – 98.0)

PPV: Positive predictive value; NPV: Negative predictive value