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. Author manuscript; available in PMC: 2019 Oct 28.
Published in final edited form as: Biochim Biophys Acta Biomembr. 2018 Apr 28;1860(9):1741–1764. doi: 10.1016/j.bbamem.2018.04.012

Figure 3. Effects of model membranes of various sizes on Aβ(1-40) amyloid fibrillation and interactions between Aβ(1-40) and membranes.

Figure 3

(A, D) Aggregation kinetics monitored by ThT fluorescence in the absence (black) or presence of DOPC vesicles of 30 (pink) (A) and 100 nm [95] (D) at 37 °C without shaking. DOPC lipids in vesicles and Aβ concentrations were 10 μM. (B, E) AFM images of amyloid fibrils formed in the presence of DOPC vesicles of 30 (B) and 100 nm (E). (C, F) ITC measurements for DOPC vesicle:Aβ(1-40) interactions. ITC thermograms (upper panel) and binding isotherms (lower panel) for vesicles of 30 (C) or 100 nm (F). Figures were reproduced from reference [48].