Fig. 3. Effects of C3G on Aβ_25–35-induced [Zn²⁺]_i increases.

(A) Treatment with Aβ_25–35 (20 µM) for 10 min increased [Zn²⁺]_i increases (n=26). (B, C) Pretreatment with C3G (10 µg/ml) for 30 min significantly inhibited the Aβ_25–35-induced [Zn²⁺]_i responses (n=22). (C) Aβ_25–35 induced response is normalized to the initial value measured before the addition of agonist. Data are expressed as mean±S.E. ^**p<0.01 relative to control (non-paired Student's t-test).