Figure 1.

Identification of cortical lesions. (A,B) Low magnification images of brain coronal sections labeled with tomato lectin (TL) to label the infiltrates surrounding the lesions. In experimental autoimmune encephalomyelitis (EAE)-induced mice (A) cell infiltrates were located along the brain, while in sham animals (B), no lesions or infiltrates were identified. In EAE animals, affected areas (boxed with dotted line) were subcortical white matter (C,E), cortical/subcortical area (C,D) and layer I (subpial, F). Scale bars: (A,B) 400 μm and (C–F) 100 μm.