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. 2018 Oct 23;8:372. doi: 10.3389/fcimb.2018.00372

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Copyright © 2018 Azagra-Boronat, Massot-Cladera, Knipping, van't Land, Stahl, Garssen, Rodríguez-Lagunas, Franch, Castell and Pérez-Cano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Assessment of oligosaccharide supplementation on the intestinal barrier function. The effects on the intestinal barrier function was studied at the peak of diarrhea (day 8). (A) The alpha-1 antitrypsin (A1AT) concentration in the gut wash was analyzed by ELISA as a measure of the intestinal barrier disruption. (B) Relative expression of tight junction molecules Cldn2 and Ocln and the mucin Muc2 were quantified by real-time PCR. Relative gene expression was calculated with respect to REF, which corresponded to 100% of transcription. Results are expressed as mean ± S.E.M. (n = 4–8). *p < 0.05 compared to REF group; ^#p < 0.05 compared to RV group (by MWU test).